Gene information
Official symbol INSR
Official full name insulin receptor
Gene type protein-coding gene
Chromosome19p13.2
Alias symbolCD220
Gene familyReceptor tyrosine kinases; CD molecules; Fibronectin type III domain containing
Resources
Entrez Gene 3643
HGNC HGNC:6091
Ensembl ENSG00000171105
Vega OTTHUMG00000181992
UCSC uc002mgd.2
GO terms: 165 records
GO Description Category LogP Number of genes Detail
GO:0001540 amyloid-beta binding GO Molecular Functions -10.7345181 13 More
GO:0003007 heart morphogenesis GO Biological Processes -18.8519524 49 More
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0003018 vascular process in circulatory system GO Biological Processes -47.1670528 52 More
GO:0004672 protein kinase activity GO Molecular Functions -2.03527804 36 More
GO:0004713 protein tyrosine kinase activity GO Molecular Functions -1.63313364 5 More
GO:0004714 transmembrane receptor protein tyrosine kinase activity GO Molecular Functions -3.13739094 5 More
GO:0005159 insulin-like growth factor receptor binding GO Molecular Functions -3.41433421 5 More
GO:0005520 insulin-like growth factor binding GO Molecular Functions -5.13373504 7 More
GO:0005525 GTP binding GO Molecular Functions -2.71464718 14 More
GO:0005635 nuclear envelope GO Cellular Components -2.52835717 16 More
GO:0005770 late endosome GO Cellular Components -2.28850711 22 More
GO:0005901 caveola GO Cellular Components -18.8033423 19 More
GO:0005975 carbohydrate metabolic process GO Biological Processes -4.30473825 38 More
GO:0005979 regulation of glycogen biosynthetic process GO Biological Processes -6.48443546 10 More
GO:0006109 regulation of carbohydrate metabolic process GO Biological Processes -13.1742479 35 More
GO:0006110 regulation of glycolytic process GO Biological Processes -6.41532756 12 More
GO:0006140 regulation of nucleotide metabolic process GO Biological Processes -7.41911571 18 More
GO:0006468 protein phosphorylation GO Biological Processes -5.36604576 56 More
GO:0006897 endocytosis GO Biological Processes -8.07395492 24 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO Biological Processes -16.7048742 60 More
GO:0007507 heart development GO Biological Processes -29.3002557 91 More
GO:0007548 sex differentiation GO Biological Processes -7.13021119 33 More
GO:0007610 behavior GO Biological Processes -18.1916656 76 More
GO:0007611 learning or memory GO Biological Processes -7.55755517 33 More
GO:0007612 learning GO Biological Processes -4.32260958 18 More
GO:0007613 memory GO Biological Processes -4.31484432 16 More
GO:0008286 insulin receptor signaling pathway GO Biological Processes -3.0699689 9 More
GO:0008544 epidermis development GO Biological Processes -5.40298147 17 More
GO:0008584 male gonad development GO Biological Processes -2.74541064 14 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0009896 positive regulation of catabolic process GO Biological Processes -13.5088608 63 More
GO:0009897 external side of plasma membrane GO Cellular Components -28.0033937 46 More
GO:0010008 endosome membrane GO Cellular Components -3.11007663 16 More
GO:0010232 vascular transport GO Biological Processes -6.06441304 9 More
GO:0010638 positive regulation of organelle organization GO Biological Processes -6.49207636 47 More
GO:0010675 regulation of cellular carbohydrate metabolic process GO Biological Processes -9.60411715 27 More
GO:0010676 positive regulation of cellular carbohydrate metabolic process GO Biological Processes -6.37680507 13 More
GO:0010827 regulation of glucose transmembrane transport GO Biological Processes -18.4601079 28 More
GO:0010828 positive regulation of glucose transmembrane transport GO Biological Processes -9.82015489 15 More
GO:0010906 regulation of glucose metabolic process GO Biological Processes -10.3110629 25 More
GO:0010907 positive regulation of glucose metabolic process GO Biological Processes -8.00848642 13 More
GO:0010962 regulation of glucan biosynthetic process GO Biological Processes -6.48443546 10 More
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO Biological Processes -15.9250248 30 More
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO Biological Processes -18.2876323 28 More
GO:0016032 viral process GO Biological Processes -8.84449931 34 More
GO:0017046 peptide hormone binding GO Molecular Functions -2.85990067 8 More
GO:0018108 peptidyl-tyrosine phosphorylation GO Biological Processes -3.43405510 8 More
GO:0018212 peptidyl-tyrosine modification GO Biological Processes -3.37492500 8 More
GO:0019001 guanyl nucleotide binding GO Molecular Functions -3.38049334 16 More
GO:0019058 viral life cycle GO Biological Processes -10.6409496 31 More
GO:0019199 transmembrane receptor protein kinase activity GO Molecular Functions -5.31743835 14 More
GO:0019904 protein domain specific binding GO Molecular Functions -3.48133193 23 More
GO:0030100 regulation of endocytosis GO Biological Processes -14.0757782 22 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030424 axon GO Cellular Components -6.14132550 54 More
GO:0030425 dendrite GO Cellular Components -4.55233052 48 More
GO:0031016 pancreas development GO Biological Processes -6.43498850 15 More
GO:0031252 cell leading edge GO Cellular Components -1.97716247 28 More
GO:0031253 cell projection membrane GO Cellular Components -3.08510132 12 More
GO:0031331 positive regulation of cellular catabolic process GO Biological Processes -13.5134767 30 More
GO:0031994 insulin-like growth factor I binding GO Molecular Functions -5.14025860 6 More
GO:0032147 activation of protein kinase activity GO Biological Processes -11.6086663 28 More
GO:0032148 activation of protein kinase B activity GO Biological Processes -8.71311579 12 More
GO:0032561 guanyl ribonucleotide binding GO Molecular Functions -3.38049334 16 More
GO:0032868 response to insulin GO Biological Processes -11.6850377 35 More
GO:0032869 cellular response to insulin stimulus GO Biological Processes -9.16399556 26 More
GO:0032870 cellular response to hormone stimulus GO Biological Processes -24.7707938 79 More
GO:0032881 regulation of polysaccharide metabolic process GO Biological Processes -7.60302561 13 More
GO:0032885 regulation of polysaccharide biosynthetic process GO Biological Processes -7.40593429 12 More
GO:0033218 amide binding GO Molecular Functions -9.50305686 47 More
GO:0033500 carbohydrate homeostasis GO Biological Processes -23.7918768 50 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0034330 cell junction organization GO Biological Processes -7.96624809 49 More
GO:0034762 regulation of transmembrane transport GO Biological Processes -31.7284805 100 More
GO:0034764 positive regulation of transmembrane transport GO Biological Processes -18.2616571 46 More
GO:0035270 endocrine system development GO Biological Processes -10.2307745 25 More
GO:0038024 cargo receptor activity GO Molecular Functions -11.0179524 13 More
GO:0040008 regulation of growth GO Biological Processes -30.7609323 104 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042277 peptide binding GO Molecular Functions -10.2245210 22 More
GO:0042562 hormone binding GO Molecular Functions -4.16724021 13 More
GO:0042593 glucose homeostasis GO Biological Processes -23.8963802 50 More
GO:0043025 neuronal cell body GO Cellular Components -9.18558636 52 More
GO:0043235 receptor complex GO Cellular Components -19.4198369 40 More
GO:0043243 positive regulation of protein-containing complex disassembly GO Biological Processes -3.26415888 7 More
GO:0043244 regulation of protein-containing complex disassembly GO Biological Processes -2.18901367 12 More
GO:0043255 regulation of carbohydrate biosynthetic process GO Biological Processes -8.87798147 21 More
GO:0043405 regulation of MAP kinase activity GO Biological Processes -18.9267681 42 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043434 response to peptide hormone GO Biological Processes -26.1739008 69 More
GO:0043467 regulation of generation of precursor metabolites and energy GO Biological Processes -10.8295915 27 More
GO:0043470 regulation of carbohydrate catabolic process GO Biological Processes -8.06132628 15 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0044000 movement in host GO Biological Processes -9.40214314 25 More
GO:0044297 cell body GO Cellular Components -11.7206640 62 More
GO:0044298 cell body membrane GO Cellular Components -2.23601792 3 More
GO:0044409 entry into host GO Biological Processes -10.3666963 14 More
GO:0044853 plasma membrane raft GO Cellular Components -18.4542052 33 More
GO:0045121 membrane raft GO Cellular Components -30.0775030 71 More
GO:0045428 regulation of nitric oxide biosynthetic process GO Biological Processes -19.2075726 26 More
GO:0045429 positive regulation of nitric oxide biosynthetic process GO Biological Processes -13.6962150 18 More
GO:0045725 positive regulation of glycogen biosynthetic process GO Biological Processes -5.96315455 7 More
GO:0045787 positive regulation of cell cycle GO Biological Processes -4.54703082 15 More
GO:0045807 positive regulation of endocytosis GO Biological Processes -11.0143833 14 More
GO:0045821 positive regulation of glycolytic process GO Biological Processes -6.91942497 9 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0045913 positive regulation of carbohydrate metabolic process GO Biological Processes -10.1978214 20 More
GO:0045927 positive regulation of growth GO Biological Processes -20.3035639 52 More
GO:0045981 positive regulation of nucleotide metabolic process GO Biological Processes -9.35726225 15 More
GO:0045995 regulation of embryonic development GO Biological Processes -3.4998671 7 More
GO:0046324 regulation of glucose import GO Biological Processes -14.8736114 22 More
GO:0046326 positive regulation of glucose import GO Biological Processes -7.69659659 12 More
GO:0046546 development of primary male sexual characteristics GO Biological Processes -2.71532895 14 More
GO:0046661 male sex differentiation GO Biological Processes -3.36897940 17 More
GO:0046718 viral entry into host cell GO Biological Processes -10.4786216 14 More
GO:0048259 regulation of receptor-mediated endocytosis GO Biological Processes -11.3903749 15 More
GO:0048608 reproductive structure development GO Biological Processes -16.4007448 61 More
GO:0048638 regulation of developmental growth GO Biological Processes -23.5012496 63 More
GO:0048639 positive regulation of developmental growth GO Biological Processes -14.4198804 35 More
GO:0048732 gland development GO Biological Processes -26.3979320 74 More
GO:0050808 synapse organization GO Biological Processes -6.17744712 32 More
GO:0050890 cognition GO Biological Processes -8.00500082 37 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0051701 biological process involved in interaction with host GO Biological Processes -10.6054189 28 More
GO:0051785 positive regulation of nuclear division GO Biological Processes -3.17098953 5 More
GO:0051896 regulation of protein kinase B signaling GO Biological Processes -30.5149255 55 More
GO:0051897 positive regulation of protein kinase B signaling GO Biological Processes -23.7578366 39 More
GO:0055123 digestive system development GO Biological Processes -12.1524002 29 More
GO:0060627 regulation of vesicle-mediated transport GO Biological Processes -25.1756709 46 More
GO:0061458 reproductive system development GO Biological Processes -16.2516665 61 More
GO:0062012 regulation of small molecule metabolic process GO Biological Processes -26.8746473 69 More
GO:0062013 positive regulation of small molecule metabolic process GO Biological Processes -17.9792910 37 More
GO:0070848 response to growth factor GO Biological Processes -40.6139195 102 More
GO:0070873 regulation of glycogen metabolic process GO Biological Processes -6.66615417 11 More
GO:0070875 positive regulation of glycogen metabolic process GO Biological Processes -5.72938190 7 More
GO:0071363 cellular response to growth factor stimulus GO Biological Processes -39.8883675 98 More
GO:0071375 cellular response to peptide hormone stimulus GO Biological Processes -15.9961580 44 More
GO:0071417 cellular response to organonitrogen compound GO Biological Processes -26.3253267 90 More
GO:0071900 regulation of protein serine/threonine kinase activity GO Biological Processes -19.5794055 63 More
GO:0080164 regulation of nitric oxide metabolic process GO Biological Processes -19.7892071 27 More
GO:0090068 positive regulation of cell cycle process GO Biological Processes -2.40180572 9 More
GO:0097242 amyloid-beta clearance GO Biological Processes -5.57650860 8 More
GO:0097447 dendritic tree GO Cellular Components -4.82959150 49 More
GO:0098552 side of membrane GO Cellular Components -22.4625650 48 More
GO:0098797 plasma membrane protein complex GO Cellular Components -14.6387951 39 More
GO:0098802 plasma membrane signaling receptor complex GO Cellular Components -6.47096721 17 More
GO:0098857 membrane microdomain GO Cellular Components -30.8181788 72 More
GO:0099173 postsynapse organization GO Biological Processes -2.62416993 6 More
GO:0106027 neuron projection organization GO Biological Processes -2.41065089 4 More
GO:0150104 transport across blood-brain barrier GO Biological Processes -6.06441304 9 More
GO:1900542 regulation of purine nucleotide metabolic process GO Biological Processes -7.57719972 18 More
GO:1900544 positive regulation of purine nucleotide metabolic process GO Biological Processes -9.35726225 15 More
GO:1901652 response to peptide GO Biological Processes -34.9047734 89 More
GO:1901653 cellular response to peptide GO Biological Processes -21.5212108 58 More
GO:1901699 cellular response to nitrogen compound GO Biological Processes -26.9091664 96 More
GO:1903578 regulation of ATP metabolic process GO Biological Processes -8.20286273 19 More
GO:1903580 positive regulation of ATP metabolic process GO Biological Processes -9.55155535 14 More
GO:1904407 positive regulation of nitric oxide metabolic process GO Biological Processes -14.4967625 19 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
GO:2000241 regulation of reproductive process GO Biological Processes -4.23306387 21 More
GO:2000243 positive regulation of reproductive process GO Biological Processes -2.52693001 10 More
KEGG pathways: 17 records
KEGG Description Category LogP Number of genes Detail
hsa04014 Ras signaling pathway KEGG Pathway -9.01898803 33 More
hsa04022 cGMP-PKG signaling pathway KEGG Pathway -9.74555098 16 More
hsa04068 FoxO signaling pathway KEGG Pathway -6.87449445 21 More
hsa04072 Phospholipase D signaling pathway KEGG Pathway -3.77257282 17 More
hsa04150 mTOR signaling pathway KEGG Pathway -2.57210479 7 More
hsa04151 PI3K-Akt signaling pathway KEGG Pathway -29.3006421 73 More
hsa04152 AMPK signaling pathway KEGG Pathway -7.66810818 12 More
hsa04211 Longevity regulating pathway KEGG Pathway -6.96966761 10 More
hsa04213 Longevity regulating pathway - multiple species KEGG Pathway -4.02893527 6 More
hsa04910 Insulin signaling pathway KEGG Pathway -1.75646958 6 More
hsa04913 Ovarian steroidogenesis KEGG Pathway -6.83160707 8 More
hsa04923 Regulation of lipolysis in adipocytes KEGG Pathway -8.97402692 10 More
hsa04930 Type II diabetes mellitus KEGG Pathway -3.96920305 9 More
hsa04931 Insulin resistance KEGG Pathway -8.40376708 21 More
hsa04932 Non-alcoholic fatty liver disease KEGG Pathway -11.2628136 17 More
hsa04960 Aldosterone-regulated sodium reabsorption KEGG Pathway -2.02099167 3 More
hsa05010 Alzheimer disease KEGG Pathway -5.39034067 17 More
Drug-Gene interaction
view
Related drugs: 60 records
Drug name Interaction type Source PMID View
aew-541 TTD view
bms-754807 inhibitor TALCChemblInteractions view
cenisertib DTC view
ceritinib inhibitor DTC 23837797 view
cyc-116 DTC view
cyclophosphamide PharmGKB view
dovitinib inhibitor DTC view
epirubicin PharmGKB view
fluorouracil PharmGKB view
go-6976 DTC view
gw441756x DTC view
hesperadin inhibitor DTC 19035792 view
ilorasertib DTC view
insulin agonist TdgClinicalTrialChemblInteractionsTEND view
insulin aspart agonist ChemblInteractions view
insulin aspart protamine recombinant agonist ChemblInteractions view
insulin degludec agonist ChemblInteractions view
insulin detemir agonist ChemblInteractions view
insulin glargine agonist ChemblInteractions view
insulin glulisine agonist ChemblInteractions view
insulin lispro agonist ChemblInteractions view
insulin lispro protamine recombinant agonist ChemblInteractions view
insulin peglispro agonist ChemblInteractions view
insulin pork agonist ChemblInteractions view
insulin purified beef agonist ChemblInteractions view
insulin purified pork agonist ChemblInteractions view
insulin susp isophane beef agonist ChemblInteractions view
insulin susp isophane beef/pork agonist ChemblInteractions view
insulin susp isophane purified beef agonist ChemblInteractions view
insulin susp isophane purified pork agonist ChemblInteractions view
insulin susp isophane recombinant human agonist ChemblInteractions view
insulin susp isophane semisynthetic purified human agonist ChemblInteractions view
insulin susp protamine zinc beef/pork agonist ChemblInteractions view
insulin susp protamine zinc purified beef agonist ChemblInteractions view
insulin susp protamine zinc purified pork agonist ChemblInteractions view
insulin zinc susp beef agonist ChemblInteractions view
insulin zinc susp extended beef agonist ChemblInteractions view
insulin zinc susp extended purified beef agonist ChemblInteractions view
insulin zinc susp extended recombinant human agonist ChemblInteractions view
insulin zinc susp prompt beef agonist ChemblInteractions view
insulin zinc susp prompt purified pork agonist ChemblInteractions view
insulin zinc susp purified beef agonist ChemblInteractions view
insulin zinc susp purified beef/pork agonist ChemblInteractions view
insulin zinc susp purified pork agonist ChemblInteractions view
insulin zinc susp recombinant human agonist ChemblInteractions view
insulin zinc susp semisynthetic purified human agonist ChemblInteractions view
kw-2450 inhibitor ChemblInteractions view
linifanib DTC view
linsitinib inhibitor TALCChemblInteractions view
methazolamide TTD view
mitoglitazone TTD view
pf-00562271 DTC view
r-406 DTC view
recombinant human kallikrein-1 TTD view
rg-1530 DTC view
sp-600125 DTC view
tae-684 DTC view
tesofensine TTD view
topiramate PharmGKB 26524290 view
tozasertib DTC view
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
cg25679870 hypermethylation epigenomics myocardial infarction[diagnosis] myocardial infarction Rask-Andersen M et al. Hum Mol Genet. 2016
NM_000208.4:c.1650G>A genomics myocardial infarction[diagnosis] myocardial infarction Puzniak A et al. Pol Merkur Lekarski. 2002
All rights reserved: Soochow University Center for Systems Biology